CoQ10 All-Natural Dietary Supplement 60 caps 120 mg Your Price $62.00 Quantity

Benefits Improves heart function Helps reduce high blood pressure Enhances oral health Increases immunity against breast cancer Helps minamize Alzheimer’s and Parkinson’s symptoms

Dose
The optimal dose of CoQ10 is still being investigated and levels of CoQ10 decrease as people age. Low blood levels have been reported in people with heart failure, cardiomyopathy, gingivitis / periodontitis (inflammation of the gums), severe obesity, hypertension, muscular dystrophy, diabetes and AIDS.

A test to assess CoQ10 status is now available from some medical laboratories. The typical dose supported by clinical research and prescribed by physicians ranges from 30mg twice daily for palpitations, 100 mg twice daily for high blood pressure and congestive heart failure, 200 mg twice daily for Breast Cancer, to 1200 mg per day for Parkinson’s disease.

Research
Coenzyme CoQ10 has been available over the counter in the United States for about a decade, largely due to studies conducted on its potential to strengthen failing hearts. Most of the research in this area has been conducted abroad, but a small number of U.S. trials exist.

Virtually every cell of the human body contains CoQ10. The heart and liver contain the greatest amount of CoQ10. Heart muscle, because it is in constant motion, requires high amounts of CoQ10. and can be depleted even further when the heart muscle is damaged. It has been found to benefit people with Congestive Heart Failure (CHF) (2,3,4,5,6,7)

Angina patients taking 150 mg per day of CoQ10 report a greater ability to exercise without experiencing chest pain.(8) This has been confirmed in independent investigations.(9)

CoQ10 deficiency is found to be present in 39% of patients with high blood pressure. Supplementing CoQ10 in patients with hypertension has been shown to lower their blood pressure significantly. At the end of the 10-week clinical trial, the average systolic blood pressure (SBP) of the 26 patients decreased from 165 to 147 mmHg and diastolic blood pressure (DBP) decreased from 98 to 86 mmHg. What’s more, as the Plasma CoQ10 values increased the total cholesterol decreased from 223mg/dl to 213 mg/dl and serum HDL cholesterol increased from 41mg/dl to 43mg/dl.(10)

In Parkinson's disease, research has shown that free radical damage in the area of the brain responsible for movement control, leads to cell death and development of the disease. The ailment afflicts between one-million and 1½ million Americans with 50,000 new cases reported every year. CoQ10 stopped the progressive deterioration in movement that characterizes the disease by 44% in those patients who took 1200 mg daily.(11)

Healing of Periodontal Disease (the gums and bones of the mouth) may require increased energy production, which has been linked to a CoQ10 deficiency. Double-blind research shows that people with gum disease given CoQ10 achieve better results than those given a placebo.(12)

CoQ10 has also shown a small but significant benefit in treating Amyotropohic Lateral Sclerosis (ALS), and Hunington’s Disease. (13)

CoQ10 (along with iron and vitamin B6) given to several people with Alzheimer’s disease prevented the progression of the disease for one and a half, to two years.(14)

CoQ10 has been found to enhance immunity.(15) A few cases have been reported in which women with metastatic breast cancer (cancer that had spread to other tissues) had a regression of their cancer after treatment with a 390 mg CoQ10 per day.(16)

Adverse Effects
Coenzyme CoQ10 is remarkably well tolerated, with few side effects noted in the numerous trials that have studied its use. However, the beneficial effects of CoQ10 may take several months of treatment. Discontinuation of CoQ10 supplementation in people with CHF has resulted in severe relapses and should be taken under the supervision of a qualified physician.(17)

References

1. Folkers K. Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res Commun 1996 Jul 16;224(2):358-61)
2. Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drug Exptl Clin Res 1985;11:581–93.
3. Soja AM, Mortensen SA. Treatment of chornic cardiac insufficiency with coenzyme Q10, results of meta-analysis in controlled clinical trials. Ugeskr Laeger 1997;159:7302–8.
4. Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig 1993;71:S134–6.
5. Permanetter B, Rossy W, Klein G, et al. Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. Eur Heart J 1992;13:1528–33.
6. Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 1999;33:1549–52.
7. Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med 2000;132:636–40.
8. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247.
9. Mortensen SA. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Invesigt 1993;71:S116–23 [review].
10. Digiesi V, et. al., Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63.
11. (Shults CW, et.al., Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002 Oct;59(10):1541-50.
12. Gaby AR. Coenzyme Q10. In A Textbook of Natural Medicine, by Pizzorno JE, Murray MT. Seattle: Bastyr University Press, 1998, V:CoQ10–1–8. [review].
13. Beal MF, Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 2002 Apr;36(4):455-60.
14. Imagawa M, Naruse S, Tsuji S, et al. Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer’s disease. Lancet 1992;340:671 [letter].
15. Folkers K, Shizukuishi S, Takemura K, et al. Increase in levels of IgG in serum of patients treated with coenzyme Q10. Res Commun Pathol Pharmacol 1982;38:335–8.
16.Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 1995;212:172–7.
17.Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drug Exptl Clin Res 1985;11:581–93.