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Int
J Dermatol 1995 Jun;34(6):434-7
Topical
nicotinamide compared with clindamycin gel in the treatment of inflammatory
acne vulgaris.
Shalita
AR, Smith JG, Parish LC, Sofman MS, Chalker DK.
Department
of Dermatology, State University of New York, College of Medicine,
Brooklyn, USA.
Background:
Systemic and topical antimicrobials are effective in the treatment
of inflammatory acne vulgaris; however, widespread use of these
agents is becoming increasingly associated with the emergence of
resistant pathogens raising concerns about microorganism resistance
and highlighting the need for alternative nonantimicrobial agents
for the treatment of acne.
Nicotinamide gel provides potent antiinflammatory activity without
the risk of inducing bacterial resistance.
Methods:
In our double-blind investigation, the safety and efficacy of topically
applied 4% nicotinamide gel was compared to 1% clindamycin gel for
the treatment of moderate inflammatory acne vulgaris. Seventy-six
patients were randomly assigned to apply either 4% nicotinamide
gel (n = 38) or 1% clindamycin gel (n = 38) twice daily for 8 weeks.
Efficacy was evaluated at 4 and 8 weeks using a Physician's Global
Evaluation, Acne Lesion Counts, and an Acne Severity Rating.
Results: After 8 weeks, both treatments produced
comparable (P = 0.19) beneficial results in the Physician's Global
Evaluation of Inflammatory Acne; 82% of the patients treated with
nicotinamide gel and 68% treated with clindamycin gel were improved.
Both treatments produced statistically similar reductions in acne
lesions (papules/pustules; -60%, nicotinamide vs. -43%, clindamycin,
P = 0.168), and acne severity (-52% nicotinamide group vs. -38%
clindamycin group, P = 0.161).
Conclusions: These data demonstrate that 4% nicotinamide
gel is of comparable efficacy to 1% clindamycin gel in the treatment
of acne vulgaris. Because topical clindamycin, like other antimicrobials,
is associated with emergence of resistant microorganisms, nicotinamide
gel is a desirable alternative treatment for acne vulgaris.
Publication Types:
· Clinical Trial
· Multicenter Study
· Randomized Controlled Trial
PMID: 7657446
[PubMed - indexed for MEDLINE]
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